Query Tuning - High CPU and IO v/s Resposne Time

Hi,

I have a question regarding Query tuning that if it shows high CPU and IO intesive query but resposne time is ok so still nedds to be tuned or optimized?

Example:

While Runing tining script, if it shows Total_CPU_Time = 2094320785, MAx_CPU_Time = 684039, Execution counts = 94903 and total Logical Reads = 602159535 but query response time is ok then what will be the effect if i don't create the Index on filtered criteria or suggested index from the Execution plan or Tuning Advisor?

I have Index also ReBuilded and updated the stats.

I would liek to know any performance impact within a IO and COU intensive query but resposne time is ok.

Thanks.